'Till death do us part,' yep, you guessed it, if you *ahem* kill your spouse (preferably inside your house to avoid bounty) then you can re-equip the amulet and go searching for another lover, you serial killer you. If you're a male Nord, you could marry a male Orc if you wish Oh, the possibilities However, searching for love can be hard in a world fraught with civil war and dragons.
For good or bad there is a way to back out of your marriage in case you find a more suitable partner or got stuck with coyote ugly because you needed a place to couch surf. In Skyrim, you can marry anyone of any gender or race.